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A Lesson in Sleep Learning
18-11-2012
Anat Arzi and Prof. Noam Sobel
Is sleep learning possible? A new Weizmann Institute study that appeared recently in Nature Neuroscience has found that if certain odors are presented after tones are heard during sleep, people will start sniffing when they hear the tones alone – even when no odor is present – both during sleep and later, when awake. In other words, people can learn new information while they sleep, and this can unconsciously modify their waking behavior.
Sleep-learning experiments are notoriously difficult to conduct. For one thing, one must be sure that the subjects are actually asleep and stay that way during the “lessons.” The most rigorous trials of verbal sleep learning have failed to show any new knowledge taking root. While more and more research has demonstrated the importance of sleep for learning and memory consolidation, none had managed to show actual learning of new information taking place in an adult brain during sleep.
Prof. Noam Sobel and research student Anat Arzi, together with Sobel’s group in the Institute’s Neurobiology Department in collaboration with researchers from Loewenstein Hospital and the Academic College of Tel Aviv-Jaffa, chose to experiment with a type of conditioning that involves exposing subjects to a tone followed by an odor, so that they soon exhibit a similar response to the tone, alone, as they would to the odor. The pairing of tones and odors presented several advantages. Neither wakes the sleeper (in fact, certain odors promote sound sleep), yet the brain processes them and even reacts during slumber. Moreover, the sense of smell holds a unique non-verbal measure that can be observed – sniffing. The researchers found that in the case of smelling, the sleeping brain acts much as it does when awake: We inhale deeply when we smell a pleasant aroma but cut our inhalation short when assaulted by a bad smell. This variation in sniffing could be recorded whether the subjects were asleep or awake. Finally, this type of conditioning, while it may appear to be quite simple, is associated with some higher brain areas – including the hippocampus, which is involved in memory formation.
In the experiments, the subjects slept in a special lab while their sleep state was continuously monitored. (Waking up during the conditioning – even for a moment – disqualified the results.) As they slept, a tone was played, followed by an odor – either pleasant or unpleasant. Then another tone was played, followed by an odor at the opposite end of the pleasantness scale. Over the course of the night, the associations were partially reinforced, so that the subject was also exposed to just the tones. The sleeping volunteers reacted to the tones alone as if the associated odor were still present – by either sniffing deeply or taking shallow breaths.
The next day, the now awake subjects again heard the tones alone – with no accompanying odor. Although they had no conscious recollection of listening to them during the night, their breathing patterns told a different story. When exposed to tones that had been paired with pleasant odors, they sniffed deeply, whereas those tones associated with bad smells provoked short, shallow sniffs.
The team then asked whether this type of learning is tied to a particular phase of sleep. In a second experiment, they divided the sleep cycles into rapid eye movement (REM) sleep and non-REM sleep, and then induced the conditioning during only one phase or the other. Surprisingly, they found that the learned response was more pronounced during the REM phase, but the transfer of the association from sleep to waking was evident only when learning had taken place during the non-REM phase. Sobel and Arzi suggest that during REM sleep we may be more open to the influence of stimuli in our surroundings, but so-called “dream amnesia” – which makes us forget most of our dreams – may operate on any conditioning occurring in that stage of sleep. In contrast, non-REM sleep is the phase that is important for memory consolidation, so it might also play a role in this form of sleep-learning.
Sobel’s lab studies focus on the sense of smell; but Arzi intends to further investigate brain processing in altered states of consciousness such as sleep and coma. “Now that we know that some kind of sleep learning is possible,” says Arzi, “we want to find where the limits lie – what information can be learned during sleep and what information cannot.”
Prof. Noam Sobel's research is supported by the estate of Lore Lennon; the Adelis Foundation; the Nadia Jaglom Laboratory for Research in the Neurobiology of Olfaction; the James S. McDonnell Foundation 21st Century Science Scholar in Understanding Human Cognition Program; the Minerva Foundation; and the European Research Council.
