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Mutations shed light on cancer

In children, lack of a protein causes a dangerous disease. Why do cancer cells suppress the same protein?

Genes that affect only half the population will have double the mutation rate

Weizmann Institute researchers explain why genetic fertility problems can persist in a population


Pre-leukemic stem cells (top) with both mutated and healthy copies of the RUNX1 gene already display some of the characteristics of acute myeloid leukemia (AML). When the non-mutated copy of the gene is inactivated, disruptions in the spindle-assembly-checkpoint phase of cell division trigger cell death

Weizmann Institute researchers discover that a “standoff” between a mutated gene and its normal counterpart keeps certain cancer cells alive...

It All Depends

"Helper" proteins can make the difference between a disastrous mutation and one that might even be an improvement

Dr. Oren Schuldiner. Early pruning for proper growth
Dr. Oren Schuldiner is revealing how the developing brain is sculpted
Weizmann Institute Scientists Show how Proteins Beat the Evolutionary Stakes

A team of scientists at the Weizmann Institute of Science has shown one way that evolving organisms beat the...

 Playing the Odds
Error-prone gene repair may be a blessing in disguise for plants
Protein 'Heroes' Block Genetic Mutations

REHOVOT, Israel - November 12, 1997 - Researchers at the Weizmann Institute of Science have discovered that two repair...


Enzymes that repair DNA damage may end up preserving mutations in certain situations, according to new research