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Apoptosis

Prof. David Wallach
Perspective: Interview with Prof. David Wallach
17.09.2018
Cancer, Systems Biology, Molecular and Cell Biology

Do the "self-destruct" mechanisms always lead to cell death? 

Wallach and cell missing housekeeping functions
Verdict in the Cell: A Last-Minute Molecular Mechanism Prevents Cellular Death
12.07.2017
Cancer, Systems Biology, Molecular and Cell Biology, Immunology

Prof. David Wallach and his group reveal a protein that can kill a cell or save it

Dr. Valery Krizhanovsky
Getting Rid of Old Cells
17.05.2017
Personalized Medicine, Molecular and Cell Biology, Disease, Drugs & Diagnostics, Yeda Technology Transfer, Diagnostic Techniques and Drugs

Understanding why cells refuse to die may lead to treatments for age-related disease

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways
Where Two Paths Meet
01.09.2014
Cancer, Molecular and Cell Biology, Genetics

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected

Pre-leukemic stem cells (top) with both mutated and healthy copies of the RUNX1 gene already display some of the characteristics of acute myeloid leukemia (AML). When the non-mutated copy of the gene is inactivated, disruptions in the spindle-assembly-checkpoint phase of cell division trigger cell death
Leukemia Cells are Addicted to a Healthy Gene
29.09.2013
Cancer, Personalized Medicine, Molecular and Cell Biology, Genetics

Weizmann Institute researchers discover that a “standoff” between a mutated gene and its normal counterpart keeps certain cancer cells alive...

The tips of two adult fruit fly testes, viewed under a confocal microscope, are filled with dividing germ cells (green). About one quarter of these germ cells die by an alternative death pathway called germ cell death (pink and red)
Alternate Endings
05.06.2013
Cancer, Molecular and Cell Biology
A newly discovered cell-death pathway could help fight cancer
(l-r) Dr. Sigalit Boura-Halfon, Hadas Shatz-Azoulay, Dr. Eytan Elhanan, Prof. Yehial Zick, Roi Isaac, Dr. Yaron Vinik, Prof. Sanford Simpson, Itai Efodi, Prof. Rivka Pollak and Sarina Striem
Side Effects
05.06.2013
Disease, Drugs & Diagnostics

“Feel-good” drugs like Prozac may have an unwanted side effect: diabetes

Seagoing research team (l-r) Uri Sheyn, Dr. Miguel Frada, Shlomit Sharoni, Daniella Schatz, Dr. Assaf Vardi and Dr. Yoav Lehan
The Deep Blue
06.08.2012
Viruses & Microorganisms, Environment, Energy, Plants and Agriculture

Dr. Assaf Vardi and his Weizmann team joined a month-long research cruise to study the life cycle of a tiny microorganism

Budding wing from irradiated fruit fly larvae, magnified about 80 times; various aspects of apoptosis in a regular fly (left column) are compared with the mutant fly lacking the drice gene (right column). Upper row: “reporter” proteins are highlighted with green fluorescent protein; middle row: the cutting up of these reporter proteins by caspases; bottom row: numerous cells die by apoptosis in the regular fruit fly (left), whereas almost no apoptosis occurs in the fly lacking the Drice caspase (right)
The Slings and Arrows of Outrageous Cellular Fortune
11.06.2012
Cancer, Molecular and Cell Biology

What separates the cells that are prone to suicide from those that are long lived?

Cells growing under normal (l) and starvation (c and r) conditions. The green spots indicate an autophagy protein that is normally diffused in the cytoplasm, but is recruited to form autophagosomes in response to stress
One Protein, Two Programs
16.01.2012
Molecular and Cell Biology

A cell’s decision to commit suicide involves an exchange of information between two suicide mechanisms

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MRI brain scans of mice with Gaucher disease Type III. The scan of a mouse that received the new treatment (left) shows a significant reduction in tissue inflammation (blue) compared to an untreated mouse (right)

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The Weizmann Institute of Science Ranked among the World’s Top Ten Academic Institutions
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26.08.2024
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