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Autophagy

Phagophore
Mouths Wide Shut: How Cellular Cleaning Out Is Kept in Check
03.06.2024
Structural Biology, Biochemistry, Molecular and Cell Biology, Evolution and Development

Autophagic organelles found to actively restrict the size of their mouths

Dr Daniella Schatz
Staff Scientist: Dr. Daniella Schatz
04.08.2016
Viruses & Microorganisms, Evolution and Development, Genetics, Environment

A viral infection in marine microorganisms has consequences for the entire planet 

A green fluorescent-labeled protein serves as a marker for autophagy. Autophagy occurs when the protein accumulates within the relevant organelle (left); when diffused throughout the cell (right)
Fat Prospects for Cellular Recycling
09.09.2015

Fatty molecules are made-to-order when a piece of essential cellular machinery is needed 

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways
Where Two Paths Meet
01.09.2014
Cancer, Molecular and Cell Biology, Genetics

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected

Where Have all the Mitochondria Gone?
Where Have all the Mitochondria Gone?
15.05.2014
Molecular and Cell Biology, Fertility, Genetics

Weizmann Institute researchers shed light on a crucial step in fertilization
 

germination
How to Start a Revolution
31.07.2012
Genetics, Plants and Agriculture

Seed germination involves the reprogramming of the plant’s entire genome

Cells growing under normal (l) and starvation (c and r) conditions. The green spots indicate an autophagy protein that is normally diffused in the cytoplasm, but is recruited to form autophagosomes in response to stress
One Protein, Two Programs
16.01.2012
Molecular and Cell Biology

A cell’s decision to commit suicide involves an exchange of information between two suicide mechanisms

Han-Hai | Sabine Kacunko. Still from an interactive video installation, October 2009
The Upside of Self-Cannibalism
12.09.2011
Biochemistry
Cellular “trash haulers” are assembled on the spot through a unique membrane fusion process
Illustration: helping hand
Social Networking, Molecular Style
13.06.2011
Biochemistry, Cancer

When one of the cell’s garbage disposal systems is in trouble, another one lends a hand.

(l-r) Prof. Zvulun Elazar, Tomer Shpilka and Hilla Weidberg. Construction details
How to Build a Cellular Recycling Machine
30.05.2011
Biochemistry

The proper assembly of a recycling compartment is critical for the life of a cell.

 

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Burning Cancer’s Bridges

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Crystalizing Our Comprehension of Malaria

A tumor sample from a human patient with the most common type of lung cancer (adenocarcinoma). Senescent cells are highlighted by their expression of the p16 (red) and the PD-L1 (green) proteins. Cell nuclei are in blue

Unclogging the Immune System

MRI brain scans of mice with Gaucher disease Type III. The scan of a mouse that received the new treatment (left) shows a significant reduction in tissue inflammation (blue) compared to an untreated mouse (right)

Improving the Recipe for Gene Therapy

Press Releases
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27.08.2024
The Weizmann Institute of Science Ranked among the World’s Top Ten Academic Institutions
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26.08.2024
A Discovery to Set Your Heart a-Knocking
An image of tissue from the human small intestine obtained with the help of fluorescent dyes that made it possible to mark numerous proteins in parallel, thereby mapping out the various proteins produced in each part of the intestinal villi
07.08.2024
Navigating the Digestive Tract
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One Protein, Two Programs

A cell’s decision to commit suicide involves an exchange of information between two suicide mechanisms