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Cell migration

moving cells

A model of collective movement that makes some members more ready to move than others helps explain how cells migrate in the body

migrating cells

Sub-lethal levels of a “self-destruct” enzyme hold cells in place

Cytoskeletal fibers (green) and adhesion sites (orange) grow when the Arp2/3 complex is present in its hybrid version (right) compared with the regular, seven-subunit version (left). When Arp2/3 is absent altogether, the fibers and the adhesion sites deteriorate (center)

A seven-unit structure that helps a cell move can rearrange to help anchor it in place

Non-polarized cell six hours after seeding onto a compliant  fibronectin-coated substrate. Yellow shows paxillin, a protein  associated with focal adhesions

Sticky cells take their cues from the surface they adhere to