Cell migration

Feeling Their Way: How Migrating Cell Clusters Choose a Path

Feeling Their Way: How Migrating Cell Clusters Choose a Path

08.02.2021

Bioinformatics and Computational Biology, Theoretical Physics, Evolution and Development

Migrating embryonic cell groups sprout “fingers” that pull the rest of the cluster through tight junctures in the developing body

moving cells

Frustrated and Going in Circles

20.12.2018

Bioinformatics and Computational Biology, Nanoscience, Cancer, Molecular and Cell Biology

A model of collective movement that makes some members more ready to move than others helps explain how cells migrate in the body

migrating cells

The Migration of the Undead

08.11.2018

Biochemistry, Cancer, Systems Biology, Molecular and Cell Biology, Evolution and Development

Sub-lethal levels of a “self-destruct” enzyme hold cells in place

Cytoskeletal fibers (green) and adhesion sites (orange) grow when the Arp2/3 complex is present in its hybrid version (right) compared with the regular, seven-subunit version (left). When Arp2/3 is absent altogether, the fibers and the adhesion sites deteriorate (center)

When the Reshaping Tool Reshapes Itself

19.05.2014

Biochemistry, Molecular and Cell Biology

A seven-unit structure that helps a cell move can rearrange to help anchor it in place

Non-polarized cell six hours after seeding onto a compliant fibronectin-coated substrate. Yellow shows paxillin, a protein associated with focal adhesions

Touching Ground

16.01.2012

Space & Physics, Molecular and Cell Biology, Chemistry

Sticky cells take their cues from the surface they adhere to

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