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Michal Sharon

filaments melting in infected red blood cells

A collaborative effort reveals deadly malaria parasites’ pre-invasion strategy for softening up red blood cells  

turning weakness into strength

The new method may enable quality control without costly purification procedures

Prof. Michal Sharon

Prof. Michal Sharon is the recipient of the Mass Spectrometry in the Life Sciences Award by the Deutsche Gesellschaft fur Massenspektrometrie (...

Prof. Michal Sharon

Prof. Michal Sharon...

Prof. Michal Sharon

Prof. Michal Sharon...

op: Mass spectrometry, along with other methods, reveals that the protein CSNAP is the ninth subunit of the COP9 signalosome (CSN) complex. Bottom: COP9 complex subunits compared with those of the 19S proteasome suggest that CSNAP is the corresponding subunit to the smallest proteasome protein, filling in the puzzle of the “missing piece

The protein had evaded detection for decades; without it, cells may turn cancerous

A partially unfolded protein (yellow) is broken down by a “scissor”-proteasome (blue and red)

Understanding how a pair of molecular “scissors” are kept in check may help treat disease

Cytoskeletal fibers (green) and adhesion sites (orange) grow when the Arp2/3 complex is present in its hybrid version (right) compared with the regular, seven-subunit version (left). When Arp2/3 is absent altogether, the fibers and the adhesion sites deteriorate (center)

A seven-unit structure that helps a cell move can rearrange to help anchor it in place

(l-r) Drs. Yishai Levin, Michal Sharon, Maria Füzesi-Levi and Gili Ben-Nisan

The cell’s recycler is a shape shifter that is versatile, subtle and sophisticated

(l-r) Dr. Gili Ben-Nissan, Prof. Yosef Shaul, Dr. Michal Sharon and Oren Moscovitz

How does the cell keep certain vital proteins from getting recycled?