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Molecular pathways

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected

potato sprout. Image: Thinkstock

Revealing the gene network for producing the toxin in green potatoes may help improve crops

“Deregulation scores” of hundreds of brain tumor patients: Each row corresponds to a pathway (that is, a biochemical process), and each column to a sample taken from a patient. Every colored spot stands for a number – the value of the “deregulation score” of the corresponding pathway, as determined for a particular patient. Dark blue stands for the activity of the pathway in normal brain tissue, whereas dark red indicates a high level of deviation from normal behavior. The clearly distinct group of normal b

A new approach to personalized cancer therapy profiles a tumor by its biological pathways

Endoplasmic reticulum. Image: Nicolle Rager, National Science Foundation

What happens when proteins don’t “go by the book?”