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Metastatic melanoma cells. Image: NIH

Melanoma Mutations Mapped

08.07.2015
Cancer, Personalized Medicine, Molecular and Cell Biology, Disease, Drugs & Diagnostics
Scientists can now begin to make sense of the way a deadly cancer develops
PYK2 (red) and the cell-surface receptor (green) that triggers the cellular transition to a pro-metastatic state are found in the same membrane compartment (yellow) from which the transition signal is transmitted

Up Against a Triple Negative

08.07.2015
Cancer, Personalized Medicine, Molecular and Cell Biology, Disease, Drugs & Diagnostics
A signal stuck in the “on” position may hasten metastasis in certain breast cancers
Prof. Zelig Eshhar

Prof. Zelig Eshhar

27.05.2015
Cancer, Personalized Medicine, Nutrition, Stem Cells, Systems Biology, Viruses & Microorganisms, Molecular and Cell Biology, Immunology, Disease, Drugs & Diagnostics
Prof. Zelig Eshhar
Dr. Eran Elinav

Dr. Eran Elinav

11.05.2015
Personalized Medicine, Immunology, Disease, Drugs & Diagnostics
Dr. Eran Elinav
DNA repair mechanism. Image: Wikimedia Commons

Risk Assessment

28.04.2014
Biochemistry, Cancer, Personalized Medicine, Disease, Drugs & Diagnostics, Genetics
A combined DNA repair score can reveal an individual’s chances of developing lung cancer
The Weizmann Institute of Science Receives 120 Million Dollars to Establish the Nancy and Stephen Grand Israel National Center for Personalized Medicine

The Weizmann Institute of Science Receives 120 Million Dollars to Establish the Nancy and Stephen Grand Israel National Center for Personalized Medicine

11.11.2013
Personalized Medicine, Disease, Drugs & Diagnostics
The Weizmann Institute of Science is establishing, on its campus, the Nancy and Stephen Grand Israel National Center for Personalized Medicine. This...
Pre-leukemic stem cells (top) with both mutated and healthy copies of the RUNX1 gene already display some of the characteristics of acute myeloid leukemia (AML). When the non-mutated copy of the gene is inactivated, disruptions in the spindle-assembly-checkpoint phase of cell division trigger cell death

Leukemia Cells are Addicted to a Healthy Gene

29.09.2013
Cancer, Personalized Medicine, Molecular and Cell Biology, Genetics
Weizmann Institute researchers discover that a “standoff” between a mutated gene and its normal counterpart keeps certain cancer cells alive  
“Deregulation scores” of hundreds of brain tumor patients: Each row corresponds to a pathway (that is, a biochemical process), and each column to a sample taken from a patient. Every colored spot stands for a number – the value of the “deregulation score” of the corresponding pathway, as determined for a particular patient. Dark blue stands for the activity of the pathway in normal brain tissue, whereas dark red indicates a high level of deviation from normal behavior. The clearly distinct group of normal b

The Path to Personalized Prognosis

13.05.2013
Cancer, Personalized Medicine, Molecular and Cell Biology, Genetics, Bioinformatics and Computational Biology
A new approach to personalized cancer therapy profiles a tumor by its biological pathways
Dr. Ido Amit

The Gene Control Hierarchy

29.11.2012
Personalized Medicine, Molecular and Cell Biology, Immunology, Genetics
A new, automated method for mapping protein-DNA interactions may lead to advances in personalized medicine
Regulatory factor hierarchy: The highest level (top) determines a cell’s basic identity; the second (middle) shapes its properties; the third (bottom) activates genes according to changing conditions

Uncovering the Genome’s Regulatory Code

09.09.2012
Personalized Medicine, Molecular and Cell Biology, Immunology, Genetics
A new, automated method for mapping protein-DNA interactions may lead to advances in personalized medicine  

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The Weizmann Institute of Science Ranked among the World’s Top Ten Academic Institutions
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