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Cancer cell survival

Human lung cancer tissue under a microscope. The enzymes (yellow) that unmask the immune-activating molecules are found near the TREM2 receptors (red) of the tumor-assisting macrophages. This targeted unmasking can prevent damage to healthy tissues
19.11.2025

A new class of immune-activating molecules awakens anti-tumor immunity by targeting the tumor’s own defenses

A bacterial cell (elongated shape in the center) inside a glioblastoma tumor cell, as seen through an electron microscope. The black dots within the bacterium are engineered antibodies carrying gold particles that bind specifically to a component found only in bacterial cell envelopes and not in human cells
14.11.2025

Weizmann researchers, together with Beilinson and Rambam physicians, reveal that diverse bacteria reside within brain tumors, potentially...

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22.04.2025

Weizmann Institute researchers reveal how breast cancer cells enter a state of dormancy, remaining undetected for years, and why they suddenly...

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10.04.2025

Researchers in Prof. Ido Amit’s lab identify a gene that reprograms macrophages into cancer-promoting cells — and show how to switch it off

Getting Cancer to Unmask Itself
27.03.2025

Researchers from Prof. Yardena Samuels’s lab manipulated cancer cells into making themselves visible to the immune system, creating a new...

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04.11.2024

A newly developed antibody-based treatment for the most aggressive type of breast cancer might also be used to treat many other cancers

Combat team: A dendritic cell (right) and a T cell, both from a mouse with skin cancer, combined using the BiCE antibody (yellow)
18.01.2024

A new kind of immunotherapy, based on crosstalk between different immune cells, could pave the way for innovative treatments of cancer and...

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20.09.2023

Cancer alters cellular waste-processing machinery, helping it avoid detection by the immune system

Human lung cancer cells harboring the L858R mutation in the EGFR gene. Cell nuclei are in blue. The red color marks a protein that is present in the cell cytoplasm when the EGFR is active and driving the uncontrolled cell divisions
08.08.2023

Weizmann Institute researchers identify a biomarker that may one day enable a subgroup of lung cancer patients to benefit from relapse-free...

Collagen fibers deposited by fibroblasts in the tumor microenvironment, viewed under a microscope. The fibers form an orderly pattern in tumors with an unmutated BRCA gene (top); in contrast, in tumors of patients harboring BRCA mutations (bottom), the collagen structure is disordered
08.02.2023

Weizmann Institute scientists have discovered how mutations in the BRCA genes, particularly prevalent among Ashkenazi Jews, lead to...

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