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Human stem cells

A stem cell–derived human embryo model at a developmental stage equivalent to that of a human embryo at day 12 has all the compartments typical of this stage. The top sphere contains the part that will become the embryo itself, capped by the amnion; the bottom sphere is the yolk sac; the interface between them is a critical structural feature of human embryonic development. The two spheres are encapsulated by a cellular layer that will become the placenta

The complete, day 14 synthetic models may open new avenues of research into infertility, drug testing and growth of tissues for transplant – as...

Mouse embryo with integrated human cells that contribute to its development

Prof. Jacob Hanna’s method for growing mouse embryos outside the womb was shortlisted for Science’s Breakthrough of the Year. Another study from...

Mouse embryonic stem cells

Remodeling the power plants known as mitochondria are key to stem cell differentiation

Zebrafish blood vessels

Stem cells must get oriented before taking on new properties

Dr. Valery Krizhanovsky. Eliminating senescent cells from the lung

Blocking two proteins might rid the body of aging cells and promote tissue renewal

New lung cells are continuously created to replace the damaged ones: Lung tissue six weeks after stem cell transplantation (left) and 16 weeks after transplantation (right). Cells that originated in the transplanted stem cells are green, as opposed to the uncolored host lung cells. Photon-2 microscope image

Transplanted cells made their way to the lungs in mice and began producing healthy tissue


Clusters of human embryonic stem cells that were differentiated to an early germ cell (PGC) state (colored cells). Each color reveals the expression of a different gene. (l-r) NANOS3, NANOG, OCT4 and, on the right, all three combined in a single image

A cell programming technique developed at the Weizmann Institute turns them into the earliest...

(l-r) Dr. Zohar Mukamel, Zohar Shipony and Prof. Amos Tanay

As the body’s cell divide and age, mistakes can pile up in the genome's "tags"

stem state infographic

The path from stem cell to mature adult cell is not a one-way street