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Induced pluripotent stem cells

Development of synthetic mouse embryo models inside beakers
Without Egg, Sperm or Womb: Synthetic Mouse Embryo Models Created Solely from Stem Cells
01.08.2022
Stem Cells, Molecular and Cell Biology, Evolution and Development, Genetics, Technology & Applications

The method opens new vistas for studying how stem cells self-organize into organs and may in the future help produce transplantable...

Stem cells
Lowering the Handbrakes on Stem Cell Production
03.01.2019
Biochemistry, Cancer, Personalized Medicine, Stem Cells

Cells that are reprogrammed to become stem cells benefit when a protein complex is removed   

Stem cell colony with cells in the process of differentiation; from the lab of Dr. Jacob Hanna
Stopping the Stem Cell State
02.02.2015
Molecular and Cell Biology, Genetics

Before anything else, a stem cell must first put the brakes on its “stem-cell” program

Clusters of human embryonic stem cells that were differentiated to an early germ cell (PGC) state (colored cells). Each color reveals the expression of a different gene. (l-r) NANOS3, NANOG, OCT4 and, on the right, all three combined in a single image
Human Primordial Cells Created in the Lab
24.12.2014
Stem Cells, Molecular and Cell Biology, Fertility, Genetics

A cell programming technique developed at the Weizmann Institute turns them into the earliest...

New Stem Cells Go Back Further
New Stem Cells Go Back Further
31.10.2013
Stem Cells, Molecular and Cell Biology, Genetics

Scientists isolate new human pluripotent stem cells capable of generating “humanized” mouse models containing human-derived tissues
 ...

Left column: Previous method for creating induced pluripotent stem cells (iPSCs); right column: iPSCs produced with the new method developed by Dr. Hanna. Top: Skin cells (red); center: iPSCs from skin cells (green); bottom: superimposed top and center images. Skin cells that have been reprogrammed into iPSCs appear light yellow. Only a small percentage of the cells on the left have been reprogrammed, in contrast with the high success rate seen with the new method on the right
Stem Cell Reprogramming Made Easier
17.09.2013
Stem Cells, Molecular and Cell Biology, Genetics

Weizmann Institute scientists show that removing one protein from adult cells enables them to efficiently turn back the clock to a stem-cell-like...

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Credit: Coleen Murphy, Princeton University, Princeton, NJ

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27.08.2024
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A Discovery to Set Your Heart a-Knocking
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