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Apoptosis

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways
01.09.2014

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected

Pre-leukemic stem cells (top) with both mutated and healthy copies of the RUNX1 gene already display some of the characteristics of acute myeloid leukemia (AML). When the non-mutated copy of the gene is inactivated, disruptions in the spindle-assembly-checkpoint phase of cell division trigger cell death
29.09.2013

Weizmann Institute researchers discover that a “standoff” between a mutated gene and its normal counterpart keeps certain cancer cells alive...

The tips of two adult fruit fly testes, viewed under a confocal microscope, are filled with dividing germ cells (green). About one quarter of these germ cells die by an alternative death pathway called germ cell death (pink and red)
05.06.2013
A newly discovered cell-death pathway could help fight cancer
(l-r) Dr. Sigalit Boura-Halfon, Hadas Shatz-Azoulay, Dr. Eytan Elhanan, Prof. Yehial Zick, Roi Isaac, Dr. Yaron Vinik, Prof. Sanford Simpson, Itai Efodi, Prof. Rivka Pollak and Sarina Striem
05.06.2013

“Feel-good” drugs like Prozac may have an unwanted side effect: diabetes

Seagoing research team (l-r) Uri Sheyn, Dr. Miguel Frada, Shlomit Sharoni, Daniella Schatz, Dr. Assaf Vardi and Dr. Yoav Lehan
06.08.2012

Dr. Assaf Vardi and his Weizmann team joined a month-long research cruise to study the life cycle of a tiny microorganism

Budding wing from irradiated fruit fly larvae, magnified about 80 times; various aspects of apoptosis in a regular fly (left column) are compared with the mutant fly lacking the drice gene (right column). Upper row: “reporter” proteins are highlighted with green fluorescent protein; middle row: the cutting up of these reporter proteins by caspases; bottom row: numerous cells die by apoptosis in the regular fruit fly (left), whereas almost no apoptosis occurs in the fly lacking the Drice caspase (right)
11.06.2012

What separates the cells that are prone to suicide from those that are long lived?

Cells growing under normal (l) and starvation (c and r) conditions. The green spots indicate an autophagy protein that is normally diffused in the cytoplasm, but is recruited to form autophagosomes in response to stress
16.01.2012

A cell’s decision to commit suicide involves an exchange of information between two suicide mechanisms

Protein Teamwork Drives Damaged Cells To Self-Destruct
12.12.1999
Researchers at the Weizmann Institute of Science have recently deciphered part of the cellular events underlying apoptosis --...
(l-r) Liat Shachnai, Natalie Yivgi-Ohana, Prof. Atan Gross, Maria Maryanovich and Dr. Yehudit Zaltsman-Amir
01.02.2011
A newly-discovered character in the cell suicide drama may be a promising target for anti-cancer drugs

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