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DNA repair

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs


DNA repair mechanism. Image: Wikimedia Commons

A combined DNA repair score can reveal an individual’s chances of developing lung cancer

(l-r) Dr. Tuval Ben Yehezkel, Prof. Ehud Shapiro and Tamir Biezuner

Programmable devices made of biological molecules can identify exact DNA sequences in living cells

It All Depends

"Helper" proteins can make the difference between a disastrous mutation and one that might even be an improvement

Stopgap DNA Repair Needs a Second Step

One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has...

A Better DNA Molecule

Weizmann Institute Scientists Build A Better DNA Molecule

Genetic Risk Factor

Weizmann Institute scientists discover a genetic risk factor for smoking-linked head and neck cancer

Left to right: Dr. Atan Gross, Iris Kamer, Dr. Rachel Sarig, Limor Regev, Galia Oberkovitz, Dr. Hagit Niv and Dr. Yehudit Zaltsman. Cellular self-check
One protein is recruited to aid in both cell death and survival
Molecule Mechanic

Attaching a microscopic bead to a four-way DNA  junction enables scientists to catch a molecular motor in action

Dr. Uri Alon. Cell circuits

Glowing eerily in the lab, molecular “traffic lights” reveal a sophisticated, living information-processing system