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DNA repair

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction
Living with the Quick Fix
29.12.2014
Biochemistry, Cancer, Molecular and Cell Biology, Genetics

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs

 

DNA repair mechanism. Image: Wikimedia Commons
Risk Assessment
28.04.2014
Biochemistry, Cancer, Personalized Medicine, Disease, Drugs & Diagnostics, Genetics

A combined DNA repair score can reveal an individual’s chances of developing lung cancer

(l-r) Dr. Tuval Ben Yehezkel, Prof. Ehud Shapiro and Tamir Biezuner
A Proofreader for DNA
14.02.2013
Biochemistry, Bioinformatics and Computational Biology

Programmable devices made of biological molecules can identify exact DNA sequences in living cells

It All Depends
It All Depends
16.08.2010
Biochemistry, Genetics

"Helper" proteins can make the difference between a disastrous mutation and one that might even be an improvement

Stopgap DNA Repair Needs a Second Step
Stopgap DNA Repair Needs a Second Step
04.05.2009
Biochemistry, Cancer, Disease, Drugs & Diagnostics

One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has...

A Better DNA Molecule
A Better DNA Molecule
27.05.2008
Biochemistry, Math & Computer Science

Weizmann Institute Scientists Build A Better DNA Molecule

Genetic Risk Factor
Genetic Risk Factor
23.01.2007
Biochemistry, Cancer, Disease, Drugs & Diagnostics

Weizmann Institute scientists discover a genetic risk factor for smoking-linked head and neck cancer

 ...
Left to right: Dr. Atan Gross, Iris Kamer, Dr. Rachel Sarig, Limor Regev, Galia Oberkovitz, Dr. Hagit Niv and Dr. Yehudit Zaltsman. Cellular self-check
Double Agent
02.10.2005
Biochemistry, Cancer, Molecular and Cell Biology, Genetics
One protein is recruited to aid in both cell death and survival
Molecule Mechanic
Molecule Mechanic
01.10.2004
Space & Physics, Biochemistry, Molecular and Cell Biology, Genetics

Attaching a microscopic bead to a four-way DNA  junction enables scientists to catch a molecular motor in action

Dr. Uri Alon. Cell circuits
Living Digitally
01.10.2004
Space & Physics, Molecular and Cell Biology, Genetics

Glowing eerily in the lab, molecular “traffic lights” reveal a sophisticated, living information-processing system

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