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Sweetness That Comes at a Price: Sugar Substitutes May Affect the Human Body in Unanticipated Ways

18.08.2022

Bioinformatics and Computational Biology, Personalized Medicine, Nutrition, Viruses & Microorganisms, Disease, Drugs & Diagnostics

A controlled trial suggests that non-nutritive sweeteners affect the human gut microbes and may alter glucose metabolism

A cross section of a mouse liver lobule under a fluorescence microscope. The middle layer reveals an abundance of messenger RNA molecules (white dots) for the gene encoding hepcidin, the iron-regulating hormone

Gene Analysis Adds Layers to Understanding How Our Livers Function

13.02.2017

Biochemistry, Personalized Medicine, Systems Biology, Molecular and Cell Biology, Disease, Drugs & Diagnostics, Genetics

Tracking gene expression patterns for 20,000 genes in 1,500 cells revealed a mosaic of activities

Activity of a glucose-manufacturing gene in mouse liver tissue, viewed under a fluorescence microscope. A high concentration of mRNA (red dots) reveals that this activity is highest near a blood vessel (PP) that bathes the tissue in oxygen-rich blood, essential for glucose manufacture

Bursting with Activity

01.03.2015

Molecular and Cell Biology, Genetics

Fits and spurts of gene expression help the liver cope with change

Introduction

01.05.2004

Biochemistry, Molecular and Cell Biology, Immunology, Disease, Drugs & Diagnostics, Genetics, Organic Chemistry, Benefiting Humanity

Recent data show that roughly 220 million people worldwide suffer from diabetes. In 2005, an estimated 1.1 million people died...

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Credit: Coleen Murphy, Princeton University, Princeton, NJ

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