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Stem cell

Algorithm-generated comparisons among the genomes of cells from 450 tissue samples: The analysis revealed a striking similarity (red colors, upper right rectangle) in tRNA signatures among cancerous cells and healthy dividing cells, as well as a degree of similarity among the non-dividing cells (red colors, lower left rectangle), whereas no such similarity (blue) was found when dividing cells were compared with non-dividing ones

Synonyms in the gene code spell differences in cell division

Embryonic stem cells (marked in green fluorescent protein) that should become sex cells, in which the gene encoding Utx is not present. Each column shows a gene needed for sex cell development (top row – marked in red, purple and orange). After 12 days (bottom row) the expression of the four genes has stopped and, rather than develop into sperm or ova, the stem cells die

Weizmann scientists discover an enzyme that is crucial for turning back the development clock in cells

Stem cells (alkaline phosphatase staining) from the lab of Dr. Jacob Hanna

When a critical step in stem cell differentiation goes awry, it can lead to cancer

Judging DNA by Its Cover

A newly-discovered molecular mechanism might explain the link between stem cells and cancer

Top: Dr. Noa Chapal-Ilani and Yitzhak Reizel. Bottom: Drs. Rivka Adar and Shalev Itzkovitz, and Profs. Nava Dekel and Ehud Shapiro

Tracing the lineages of cells resolves some outstanding questions in biology

The two faces of BID. When duty calls, it leaves the cell nucleus to initiate cell suicide. Illustration: Elite Avni

How does one protein direct two different life-or-death activities in the cell?

Mouse cell lineage tree. Oocytes are in red, bone marrow stem cells in yellow, demonstrating that the two form separate clusters with only a distant relationship

A new method is helping to resolve controversies and answer some open questions in biology. 

The adult stem cell unit: Niches are in red. Cap cells (barbed arrowhead) are tightly associated with germ-line stem cells (outlined). Germ-line stem cells carry a spherical organelle - a fusome - which is asymmetrically localized to the side of the cap cells (arrow). Once the stem cell divides, one daughter cell loses contact with the niche and differentiates (green). The fusome in a differentiating germ cell becomes branched (arrowhead)

Nature has an ingenious method for orchestrating stem cell development.