Genetics

Single-stranded DNA (orange) interacts with the negatively (red) and positively (blue) charged parts of the protein molecule, as well as with its amino acid structures called aromatic groups (green)

Bracing Up DNA

27.07.2015

Systems Biology, Genetics, Structural Biology, Bioinformatics and Computational Biology

When DNA splits apart, the single strands get double the help to stay in shape

SuperPaths: A map of human biological pathways. Each node represents a biological pathway and every line shows a connection between pathways. Every connected set is a SuperPath containing several related pathways.

Stay Connected

27.05.2015

Genetics, Bioinformatics and Computational Biology

SuperPaths provide a global online resource of genetic interactions

We share many of our genes with sea urchins, but none of the sequences for long non-coding RNAs that regulate those genes

Looking for Links

25.05.2015

Systems Biology, Molecular and Cell Biology, Evolution and Development, Genetics, Bioinformatics and Computational Biology

Non-coding DNA sequences on an evolutionary “fast track” may hold clues to human disease

A partially unfolded protein (yellow) is broken down by a “scissor”-proteasome (blue and red)

Molecules of the Latest Cut

11.05.2015

Biochemistry, Cancer, Molecular and Cell Biology, Genetics

Understanding how a pair of molecular “scissors” are kept in check may help treat disease

Activity of a glucose-manufacturing gene in mouse liver tissue, viewed under a fluorescence microscope. A high concentration of mRNA (red dots) reveals that this activity is highest near a blood vessel (PP) that bathes the tissue in oxygen-rich blood, essential for glucose manufacture

Bursting with Activity

01.03.2015

Molecular and Cell Biology, Genetics

Fits and spurts of gene expression help the liver cope with change

A metastatic breast cancer cell under a fluorescent microscope.

Victory in Numbers

23.02.2015

Cancer, Genetics

The discovery of a new breast cancer gene holds hope for treatment

Muscle fibers of a fruit fly larva viewed under a confocal microscope: A normal fiber has normally-shaped, properly distributed nuclei (A), whereas the nuclei of fibers with mutated MSP-300 or its interacting proteins Klar and Klaroid are distorted and distributed abnormally (B, C and D)

Use It or Lose It

11.02.2015

Molecular and Cell Biology, Genetics

Why do muscles lose their strength without exercise?

Stem cell colony with cells in the process of differentiation; from the lab of Dr. Jacob Hanna

Stopping the Stem Cell State

02.02.2015

Molecular and Cell Biology, Genetics

Before anything else, a stem cell must first put the brakes on its “stem-cell” program

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction

Living with the Quick Fix

29.12.2014

Biochemistry, Cancer, Molecular and Cell Biology, Genetics

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs

Clusters of human embryonic stem cells that were differentiated to an early germ cell (PGC) state (colored cells). Each color reveals the expression of a different gene. (l-r) NANOS3, NANOG, OCT4 and, on the right, all three combined in a single image

Human Primordial Cells Created in the Lab

24.12.2014

Stem Cells, Molecular and Cell Biology, Fertility, Genetics

A cell programming technique developed at the Weizmann Institute turns them into the earliest precursors of sperm and ova

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Prof. Samuel Safran

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