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Breast cancer

Collagen fibers deposited by fibroblasts in the tumor microenvironment, viewed under a microscope. The fibers form an orderly pattern in tumors with an unmutated BRCA gene (top); in contrast, in tumors of patients harboring BRCA mutations (bottom), the collagen structure is disordered

Weizmann Institute scientists have discovered how mutations in the BRCA genes, particularly prevalent among Ashkenazi Jews, lead to...

(l-r) Dr. Ashish Noronha, Prof. Yosef Yarden, and Dr. Nishanth Belugali Nataraj

A gene for transport helps aggressive cancer cells move and spread 

Tissue sample from triple-negative breast cancer, stained for the presence of cancer cells (red) and the two types of cancer-associated fibroblasts: pCAFs (magenta) and sCAFs (green). The nuclei of all cells are stained blue

Supporting actors in cancer growth may help predict the course of the disease

LATS1 knockout

What happens when genes in a cancer-preventing pathway are absent? 

Tethered cancer cells

This finding may help solve the puzzle of certain types of aggressive metastasis 

Double treatment kills cancer cells

New Weizmann Institute of Science research provides hope for cancer patients 

PYK2 (red) and the cell-surface receptor (green) that triggers the cellular transition to a pro-metastatic state are found in the same membrane compartment (yellow) from which the transition signal is transmitted

A signal stuck in the “on” position may hasten metastasis in certain breast cancers

A metastatic breast cancer cell under a fluorescent microscope.

The discovery of a new breast cancer gene holds hope for treatment

Two Antibodies Are Better Than One

A new approach mimicking the body’s natural defenses could help treat a...