Cancer

Mutations shed light on cancer

Rare Disease is a Lens on Cancer

24.11.2015

Cancer, Personalized Medicine, Systems Biology, Molecular and Cell Biology, Disease, Drugs & Diagnostics

In children, lack of a protein causes a dangerous disease. Why do cancer cells suppress the same protein?

Bone marrow EPCR+ hematopoietic (blood-forming) stem cell in an anticoagulant niche

Blood-Forming Stem Cells' Balancing Act

03.11.2015

How does the body keep replenishing the supply of blood cells all our lives? Two pathways must work together

Metastatic melanoma cells. Image: NIH

Melanoma Mutations Mapped

08.07.2015

Cancer, Personalized Medicine, Molecular and Cell Biology, Disease, Drugs & Diagnostics

Scientists can now begin to make sense of the way a deadly cancer develops

PYK2 (red) and the cell-surface receptor (green) that triggers the cellular transition to a pro-metastatic state are found in the same membrane compartment (yellow) from which the transition signal is transmitted

Up Against a Triple Negative

08.07.2015

Cancer, Personalized Medicine, Molecular and Cell Biology, Disease, Drugs & Diagnostics

A signal stuck in the “on” position may hasten metastasis in certain breast cancers

Cultured colorectal cancer cells. Top: Cells that have become resistant to certain forms of chemotherapy and continue to thrive. Bottom: The same cells, which have had the LIP gene inserted and are then treated with chemotherapy drugs

Opposite Effects

02.07.2015

Cancer, Molecular and Cell Biology

What makes cancer cells survive chemotherapy?

Normal human colonic crypts. SMOC-2 expression (red) in the colonic stem cells demonstrates that these cells are localized in the bottoms of the crypts. Bars represent 100 micrometers (left) and 50 micrometers (right)

Colon Cancer: Taking a Step Back to Move Forward

29.06.2015

Cancer, Stem Cells, Molecular and Cell Biology

Some tumor cells in the advanced stages of colorectal cancer adopt a less mature, more stem-like, state that assists metastasis

A melanoma cancer cell is labeled with invadopodia markers in fluorescence microscopy

Support for an Invasion

14.06.2015

Cancer, Molecular and Cell Biology

How does a cancer cell push its way out of the surrounding tissue?

Prof. Zelig Eshhar

Prof. Zelig Eshhar

27.05.2015

Cancer, Personalized Medicine, Nutrition, Stem Cells, Systems Biology, Viruses & Microorganisms, Molecular and Cell Biology, Immunology, Disease, Drugs & Diagnostics

Prof. Zelig Eshhar

A partially unfolded protein (yellow) is broken down by a “scissor”-proteasome (blue and red)

Molecules of the Latest Cut

11.05.2015

Biochemistry, Cancer, Molecular and Cell Biology, Genetics

Understanding how a pair of molecular “scissors” are kept in check may help treat disease

Immortalized cells, left, pretreated with a drug that blocks the ERK signal, and right, without the pretreatment. Top cells are untreated, while the bottom ones are stimulated

To Stop Cancer: Block its Messages

30.03.2015

Cancer, Disease, Drugs & Diagnostics

Weizmann Institute scientists identify a potential drug molecule that stops cancer cells, but not healthy ones, from getting their “mail”

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Dumpster Diving in Cancer Tissue Uncovers an Immune Evasion Mechanism

A stem cell–derived human embryo model at a developmental stage equivalent to that of a human embryo at day 12 has all the compartments typical of this stage. The top sphere contains the part that will become the embryo itself, capped by the amnion; the bottom sphere is the yolk sac; the interface between them is a critical structural feature of human embryonic development. The two spheres are encapsulated by a cellular layer that will become the placenta

Human Embryo Models Grown from Stem Cells

Peripheral sensory neurons in a laboratory dish

Unlocking a Secret Nerve Cell Regenerator

Surviving on an Empty Battery

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Human Embryo Models Grown from Stem Cells

Surviving on an Empty Battery

A “Jupiter” Hotter than the Sun