Cancer

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction

Living with the Quick Fix

29.12.2014

Biochemistry, Cancer, Molecular and Cell Biology, Genetics

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs

Algorithm-generated comparisons among the genomes of cells from 450 tissue samples: The analysis revealed a striking similarity (red colors, upper right rectangle) in tRNA signatures among cancerous cells and healthy dividing cells, as well as a degree of similarity among the non-dividing cells (red colors, lower left rectangle), whereas no such similarity (blue) was found when dividing cells were compared with non-dividing ones

Cellular Signature Style

23.11.2014

Cancer, Stem Cells, Genetics

Synonyms in the gene code spell differences in cell division

receptors day and night

Tumors Might Grow Faster at Night

06.10.2014

Cancer, Molecular and Cell Biology, Bioinformatics and Computational Biology

Weizmann Institute scientists reveal that a hormone that keeps us alert also suppresses the spread of cancer

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways

Where Two Paths Meet

01.09.2014

Cancer, Molecular and Cell Biology, Genetics

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected

(l-r) Dr. Zohar Mukamel, Zohar Shipony and Prof. Amos Tanay

Cellular Senior Moments

21.07.2014

Cancer, Stem Cells, Molecular and Cell Biology, Immunology, Genetics, Bioinformatics and Computational Biology

As the body’s cell divide and age, mistakes can pile up in the genome's "tags"

DNA repair mechanism. Image: Wikimedia Commons

Risk Assessment

28.04.2014

Biochemistry, Cancer, Personalized Medicine, Disease, Drugs & Diagnostics, Genetics

A combined DNA repair score can reveal an individual’s chances of developing lung cancer

Pre-leukemic stem cells (top) with both mutated and healthy copies of the RUNX1 gene already display some of the characteristics of acute myeloid leukemia (AML). When the non-mutated copy of the gene is inactivated, disruptions in the spindle-assembly-checkpoint phase of cell division trigger cell death

Leukemia Cells are Addicted to a Healthy Gene

29.09.2013

Cancer, Personalized Medicine, Molecular and Cell Biology, Genetics

Weizmann Institute researchers discover that a “standoff” between a mutated gene and its normal counterpart keeps certain cancer cells alive

Without the c-Kit gene, colon cancer cells grow in a disorderly, aggregated manner and are invasive (A); when c-Kit expression is restored in these cells, they revert to a more normal organization (B)

The Double Life of a Cancer Gene

15.09.2013

Space & Physics, Cancer, Molecular and Cell Biology, Genetics, Bioinformatics and Computational Biology

A cancer-causing gene can prevent the deadly spread of a tumor at a later point in malignancy

Where Lab and Clinic Meet- Dr. Ayelet Erez Work

Where Lab and Clinic Meet

02.09.2013

Cancer, Molecular and Cell Biology, Disease, Drugs & Diagnostics

Dr. Ayelet Erez finds that clinical work and lab research are a powerful combination

The tips of two adult fruit fly testes, viewed under a confocal microscope, are filled with dividing germ cells (green). About one quarter of these germ cells die by an alternative death pathway called germ cell death (pink and red)

Alternate Endings

05.06.2013

Cancer, Molecular and Cell Biology

A newly discovered cell-death pathway could help fight cancer

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