Weizmann Institute

Cancer

Prof. Lea Eisenbach

Cold War against Cancer

11.03.2015

Combining two innovative treatments might help keep cancer from spreading

(l-r) bottom: Tamar Gross, Prof. Lea Eisenbach, Dr. Esther Tzehoval and Zoya Alteber; middle row: David Bassan and Adi Sharbi-Yunger; top row: Lior Roitman, Mareike Grees and Adam Solomon

Seek and Destroy

11.02.2015

New strategies might help the immune system outwit cancer cells

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction

Living with the Quick Fix

29.12.2014

Biochemistry, Cancer, Molecular and Cell Biology, Genetics

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs

receptors day and night

Tumors Might Grow Faster at Night

06.10.2014

Cancer, Molecular and Cell Biology, Bioinformatics and Computational Biology

Weizmann Institute scientists reveal that a hormone that keeps us alert also suppresses the spread of cancer

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways

Where Two Paths Meet

01.09.2014

Cancer, Molecular and Cell Biology, Genetics

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected

(l-r) Dr. Zohar Mukamel, Zohar Shipony and Prof. Amos Tanay

Cellular Senior Moments

21.07.2014

Cancer, Stem Cells, Molecular and Cell Biology, Immunology, Genetics, Bioinformatics and Computational Biology

As the body’s cell divide and age, mistakes can pile up in the genome's "tags"

Without the c-Kit gene, colon cancer cells grow in a disorderly, aggregated manner and are invasive (A); when c-Kit expression is restored in these cells, they revert to a more normal organization (B)

The Double Life of a Cancer Gene

15.09.2013

Space & Physics, Cancer, Molecular and Cell Biology, Genetics, Bioinformatics and Computational Biology

A cancer-causing gene can prevent the deadly spread of a tumor at a later point in malignancy

Where Lab and Clinic Meet- Dr. Ayelet Erez Work

Where Lab and Clinic Meet

02.09.2013

Cancer, Molecular and Cell Biology, Disease, Drugs & Diagnostics

Dr. Ayelet Erez finds that clinical work and lab research are a powerful combination

The tips of two adult fruit fly testes, viewed under a confocal microscope, are filled with dividing germ cells (green). About one quarter of these germ cells die by an alternative death pathway called germ cell death (pink and red)

Alternate Endings

05.06.2013

Cancer, Molecular and Cell Biology

A newly discovered cell-death pathway could help fight cancer

“Deregulation scores” of hundreds of brain tumor patients: Each row corresponds to a pathway (that is, a biochemical process), and each column to a sample taken from a patient. Every colored spot stands for a number – the value of the “deregulation score” of the corresponding pathway, as determined for a particular patient. Dark blue stands for the activity of the pathway in normal brain tissue, whereas dark red indicates a high level of deviation from normal behavior. The clearly distinct group of normal b

The Path to Personalized Prognosis

13.05.2013

Cancer, Personalized Medicine, Molecular and Cell Biology, Genetics, Bioinformatics and Computational Biology

A new approach to personalized cancer therapy profiles a tumor by its biological pathways

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Israeli Researchers to Participate in European Commission Flagship

The European Commission has officially announced the selection of the Human Brain Project (HBP) as one of its two Future Emerging Technologies (FET) Flagship projects.