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“Deregulation scores” of hundreds of brain tumor patients: Each row corresponds to a pathway (that is, a biochemical process), and each column to a sample taken from a patient. Every colored spot stands for a number – the value of the “deregulation score” of the corresponding pathway, as determined for a particular patient. Dark blue stands for the activity of the pathway in normal brain tissue, whereas dark red indicates a high level of deviation from normal behavior. The clearly distinct group of normal b

A new approach to personalized cancer therapy profiles a tumor by its biological pathways

Lung cancer. Image: Lange 123 on Wikimedia commons

Activity levels of a second DNA repair mechanism improve prediction of lung cancer risk

(l-r) Dr. Ofer Shoshani and Prof. Dov Zipori
Future stem cell therapies might depend on our ability to chose those that won’t turn...
(l-r) Amir Bar, Dr. Amos Tanay, Netta Mendelson-Cohen, Prof. Varda Rotter, Dr. Zohar Mukamel, Naomi Goldfinger, Gilad Landan and Dr. Alina Molchadsky

Surprising changes in certain genomic markers may help explain how cells can turn cancerous as they age and divide

Two Antibodies Are Better Than One

A new approach mimicking the body’s natural defenses could help treat a...

Drs. Yotam Drier (left) and Gad Getz at the Broad Institute

A unique collaboration is helping map out the genetics of cancer

Stem cells (alkaline phosphatase staining) from the lab of Dr. Jacob Hanna

When a critical step in stem cell differentiation goes awry, it can lead to cancer

(l-r) Dr. Gili Ben-Nissan, Prof. Yosef Shaul, Dr. Michal Sharon and Oren Moscovitz

How does the cell keep certain vital proteins from getting recycled?

Judging DNA by Its Cover

A newly-discovered molecular mechanism might explain the link between stem cells and cancer

Kill the Messenger

A molecule developed at the Institute can intercept potentially cancer-promoting messages before they reach the cell nucleus