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Cancer

PYK2 (red) and the cell-surface receptor (green) that triggers the cellular transition to a pro-metastatic state are found in the same membrane compartment (yellow) from which the transition signal is transmitted
08.07.2015

A signal stuck in the “on” position may hasten metastasis in certain breast cancers

A partially unfolded protein (yellow) is broken down by a “scissor”-proteasome (blue and red)
11.05.2015

Understanding how a pair of molecular “scissors” are kept in check may help treat disease

Immortalized cells, left, pretreated with a drug that blocks the ERK signal, and right, without the pretreatment. Top cells are untreated, while the bottom ones are stimulated
30.03.2015

Weizmann Institute scientists identify a potential drug molecule that stops cancer cells, but not healthy ones, from getting their “mail”

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Prof. Lea Eisenbach
11.03.2015

Combining two innovative treatments might help keep cancer from spreading

(l-r) bottom: Tamar Gross, Prof. Lea Eisenbach, Dr. Esther Tzehoval and Zoya Alteber; middle row: David Bassan and Adi Sharbi-Yunger; top row: Lior Roitman, Mareike Grees and Adam Solomon
11.02.2015

New strategies might help the immune system outwit cancer cells

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction
29.12.2014

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs

 

receptors day and night
06.10.2014

Weizmann Institute scientists reveal that a hormone that keeps us alert also suppresses the spread of cancer

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways
01.09.2014

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected

(l-r) Dr. Zohar Mukamel, Zohar Shipony and Prof. Amos Tanay
21.07.2014

As the body’s cell divide and age, mistakes can pile up in the genome's "tags"

Without the c-Kit gene, colon cancer cells grow in a disorderly, aggregated manner and are invasive (A); when c-Kit expression is restored in these cells, they revert to a more normal organization (B)
15.09.2013

A cancer-causing gene can prevent the deadly spread of a tumor at a later point in malignancy

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