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Embryonic development

Neuron extensions with low NO

How do neurons decide when to grow and when to stop growing?

Stem cell colony with cells in the process of differentiation; from the lab of Dr. Jacob Hanna

Before anything else, a stem cell must first put the brakes on its “stem-cell” program

Developing bone in normal (top) and mutant (bottom) embryos. Protrusions in a developing bone are formed by a distinct class of cells (green) that differ from the regular bone-forming cells (yellow-orange). Incorrect regulation and distribution of these cells leads to irregularities in the shape of the forming bone

How does an oxygen-demanding biological process cope with low-oxygen conditions?

All Together Now

How do animal embryos take up all the calcium they need to build skeletons, shells or spines?

Sculpture: Igor Mitoraj

Factors that direct the formation of the heart and face must network during embryonic development

Dorsal-GFP displaying a gradient of nuclear localization

How does the fertilized egg start the process of becoming a diversified organism?

Embryonic stem cells (marked in green fluorescent protein) that should become sex cells, in which the gene encoding Utx is not present. Each column shows a gene needed for sex cell development (top row – marked in red, purple and orange). After 12 days (bottom row) the expression of the four genes has stopped and, rather than develop into sperm or ova, the stem cells die

Weizmann scientists discover an enzyme that is crucial for turning back the development clock in cells

The patterns on these butterfly wings are perfectly scaled, even though they are different sizes

How does a growing, developing organism keep everything in proportion?

Scale Models

How do organisms keep everything in proportion as they grow and develop?

(l-r) Prof. Varda Rotter, Dr. Eldad Tzahor, Dr. Ariel Rinon, Alina Molchadsky and Dr. Rachel Sarig. Migration regulation

A gene that protects us from cancer is also involved in the timing of a crucial stage of embryonic development.