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Eytan Domany

Gene expression of schizophrenia-related genes. 1,028 genes with very similar expression profiles are shown, one to a row, and 480 samples are arrayed in the columns. Red-to-blue shows the strength of the gene's expression level, red being stronger

New research reveals a cluster of genetic “typos” that may increase the risk of schizophrenia

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs


receptors day and night

Weizmann Institute scientists reveal that a hormone that keeps us alert also suppresses the spread of cancer

Without the c-Kit gene, colon cancer cells grow in a disorderly, aggregated manner and are invasive (A); when c-Kit expression is restored in these cells, they revert to a more normal organization (B)

A cancer-causing gene can prevent the deadly spread of a tumor at a later point in malignancy

Dr. Danny Kandel

Dr. Danny Kandel, Senior Director of Advanced Development for KLA-Tencor, Israel, develops ultra-precise measurement systems

“Deregulation scores” of hundreds of brain tumor patients: Each row corresponds to a pathway (that is, a biochemical process), and each column to a sample taken from a patient. Every colored spot stands for a number – the value of the “deregulation score” of the corresponding pathway, as determined for a particular patient. Dark blue stands for the activity of the pathway in normal brain tissue, whereas dark red indicates a high level of deviation from normal behavior. The clearly distinct group of normal b

A new approach to personalized cancer therapy profiles a tumor by its biological pathways

Drs. Yotam Drier (left) and Gad Getz at the Broad Institute

A unique collaboration is helping map out the genetics of cancer

Stem cells (alkaline phosphatase staining) from the lab of Dr. Jacob Hanna

When a critical step in stem cell differentiation goes awry, it can lead to cancer

Judging DNA by Its Cover

A newly-discovered molecular mechanism might explain the link between stem cells and cancer

Prof. Yosef Yarden, Dr. Wolfgang Köstler, Amit Zeisel and Prof. Eytan Domany

Bits of gene code that are normally discarded have found a surprising new use in research