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Protein evolution

Shutterstock
14.02.2024

Using three AI protein prediction tools, a Chinese-Israeli study uncovers new wrinkles in the folding story of “orphan” proteins

An illustration showing four modular enzyme fragments (highlighted) that Weizmann Institute’s CADENZ method can combine to generate active enzymes at a hitherto unseen rate
12.01.2023

In a major step toward greener industry, Weizmann Institute scientists create a computational method for generating enzymes with unprecedented...

Tiny droplets formed by peptides and RNA, viewed under a microscope
06.12.2022

Recreating conditions that may have existed before the dawn of life, researchers watched droplets give rise to possible precursors of today’s...

Shutterstock
14.09.2022

How did amino acids start bonding to form proteins? Weizmann Institute of Science researchers bring their findings to life in their...

How
25.02.2021

A look at enzyme evolution suggests life figured out how to use oxygen long before the main event 

Proteins with primitive arginine-based proteins (right) might have been capable of self-assembly and phase separation to create cell-like droplets
22.06.2020

An experiment in reconstructing primordial proteins solves a long-standing riddle

disordered protein
27.01.2020

Once discarded from studies, disordered segments are now understood to have important roles to play in the cell

mistakes
01.08.2019

Mapping where these errors occur was a feat they said couldn't be done. It turns out many are not random

p loops
01.04.2019

Proto-enzymes designed in the lab bound strongly to RNA and DNA, suggesting a surprising origin for these proteins

Designed and experimental antibody
26.09.2017

Including “non-ideal” components in the designs may be key to functional artificial proteins  

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