An experiment in reconstructing primordial proteins solves a long-standing riddle
Once discarded from studies, disordered segments are now understood to have important roles to play in the cell
Mapping where these errors occur was a feat they said couldn't be done. It turns out many are not random
Proto-enzymes designed in the lab bound strongly to RNA and DNA, suggesting a surprising origin for these proteins
Including “non-ideal” components in the designs may be key to functional artificial proteins
A “one-stop,” computer-design “shop” for stabilizing problematic proteins
From solving the structure of crystallized proteins to creating computer simulations of protein dynamics, Institute scientists...