You are here

Protein evolution

Designed and experimental antibody

Including “non-ideal” components in the designs may be key to functional artificial proteins  

protein repair shop

A “one-stop,” computer-design “shop” for stabilizing problematic proteins

Weizmann Institute Scientists used Accelerated Evolution to Develop: Enzymes that Provide Protection Against Nerve Gas
Protection against nerve gas attack is a significant component of the defense system of many countries around the world....
Three-dimensional structure of an enzyme, serum paraoxonase (PON1), which has been mutated in the lab of Prof. Dan Tawfik through directed evolution to endow the enzyme with new functions

From solving the structure of crystallized proteins to creating computer simulations of protein dynamics, Institute scientists...

Prof. Dan Tawfik. Saving mutations
Protein "babysitters" could speed up evolution in the lab
The enzyme’s structure (blue), revealed via X-ray crystallography, closely matches its computer design (gray). The yellow structure in the center is the substrate molecule the enzyme acts upon
Evolution in a test tube takes enzyme design to a new level
Birth of an Enzyme
Scientists succeed in designing artificial enzymes that also undergo 'evolution in a test tube'
Drs. Dan Tawfik and Amir Aharoni. Pondering PON

Why are some people less prone to heart disease or neuronal damage? An elusive protein named PON might be the answer