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Biological Chemistry

op: Mass spectrometry, along with other methods, reveals that the protein CSNAP is the ninth subunit of the COP9 signalosome (CSN) complex. Bottom: COP9 complex subunits compared with those of the 19S proteasome suggest that CSNAP is the corresponding subunit to the smallest proteasome protein, filling in the puzzle of the “missing piece

The protein had evaded detection for decades; without it, cells may turn cancerous

 Locations of different opsins on the human sperm, viewed under a microscope, are revealed by labeling with a fluorescent antibody (bright yellow)

Proteins better known as visual sensors play a role in the heat-seeking movement of sperm...

A green fluorescent-labeled protein serves as a marker for autophagy. Autophagy occurs when the protein accumulates within the relevant organelle (left); when diffused throughout the cell (right)

Fatty molecules are made-to-order when a piece of essential cellular machinery is needed 

A partially unfolded protein (yellow) is broken down by a “scissor”-proteasome (blue and red)

Understanding how a pair of molecular “scissors” are kept in check may help treat disease

NPM1 interacts with DNA polymerase eta and regulates polymerase eta-promoted TLS. Assay of polymerase eta and NPM1 in unirradiated (l) and ultraviolet irradiated cells ((c) after one hour, (r) after 18 hours). Blue: DNA in the nucleus; green: polymerase eta–NPM1 interaction

A mechanism for keeping DNA repair mistakes to a minimum might advance the development of cancer drugs


Prof. Haim Garty, z"l

The boy who grew up in the “backyard” of the Institute became an esteemed scientist and Vice President of the “wonderful place”

YEDA-XL-Protein GmbH Agreement

Combining two technologies makes a drug compound stronger and longer-lasting

(l-r) Drs. Yael Elbaz-Alon and Maya Schuldiner

A cellular organelle reveals a surprising backup resource for obtaining important building materials

how the IFN Antagonist Affects Type 1 IFN responses to pathogens

Virus-killing molecules may need all their skills, including inflammation, to fight HIV infection

Cytoskeletal fibers (green) and adhesion sites (orange) grow when the Arp2/3 complex is present in its hybrid version (right) compared with the regular, seven-subunit version (left). When Arp2/3 is absent altogether, the fibers and the adhesion sites deteriorate (center)

A seven-unit structure that helps a cell move can rearrange to help anchor it in place