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Cancer genetics

Mutations shed light on cancer

In children, lack of a protein causes a dangerous disease. Why do cancer cells suppress the same protein?

Algorithm-generated comparisons among the genomes of cells from 450 tissue samples: The analysis revealed a striking similarity (red colors, upper right rectangle) in tRNA signatures among cancerous cells and healthy dividing cells, as well as a degree of similarity among the non-dividing cells (red colors, lower left rectangle), whereas no such similarity (blue) was found when dividing cells were compared with non-dividing ones

Synonyms in the gene code spell differences in cell division

Without the c-Kit gene, colon cancer cells grow in a disorderly, aggregated manner and are invasive (A); when c-Kit expression is restored in these cells, they revert to a more normal organization (B)

A cancer-causing gene can prevent the deadly spread of a tumor at a later point in malignancy

“Deregulation scores” of hundreds of brain tumor patients: Each row corresponds to a pathway (that is, a biochemical process), and each column to a sample taken from a patient. Every colored spot stands for a number – the value of the “deregulation score” of the corresponding pathway, as determined for a particular patient. Dark blue stands for the activity of the pathway in normal brain tissue, whereas dark red indicates a high level of deviation from normal behavior. The clearly distinct group of normal b

A new approach to personalized cancer therapy profiles a tumor by its biological pathways

Prof. Rivka Dikstein

A newly discovered protein may present a suitably narrow target for cancer treatments

Prof. Roy Bar-Ziv and Dr. Lior Nissim. Identifying cancer

A new genetic sensor kills only the malignant cancer cells in a test tube.

(l-r) Gilad Landan, Dr. Amos Tanay and Rami Jaschek. New targets for treatment
Cancer-enhancing DNA may reside in a surprising part of the genome
(l-r) Dr. Perry Stambolsky and Profs. Varda Rotter and Moshe Oren
Weizmann scientists celebrate three decades of research into the p53 tumor supressor research
Dr. Eran Segal. Finding a common theme

A new computer program enables scientists to pinpoint a cancer-causing gene

Activity of 400 genes following exposure to a growth signal over time.  Red indicates hightened gene activity
Tracing the activities of hundreds of genes reveals a cancer-prevention system...