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(l-r) Osnat Tirosh, Nir Fluman and Prof. Eitan Bibi

Scientists reveal one of bacteria’s secret weapons against antibiotics

 Prof. Dan Tawfik, Dr. Mikael Elias, Korina Goldin and Alon Wellner

How do bacteria cope with toxins that resemble nutrients?

Rejecting Arsenate

Institute scientists reveal how bacteria living in toxic environments identify and expel the poison



Proteins must match up correctly to catch a ride from one site to another in the cell

(l-r) Ido Kaminsky, Prof. Eitan Reuveny, Ruth Meller, Raz Palty and Dr. Adi Raveh. Steady supply

What keeps a cellular “warehouse” from overfilling?

The molecular structure of Spanish flu protein (hemagglutin) bound to a computationally designed protein (green). The designed protein binds the viral protein tightly and with high specificity, blocking the protein's function and neutralizing viral infectivity

 A new method of redesigning protein molecules may yield novel drugs.

Prof. Gideon Schreiber

A new technique enables researchers to watch as proteins interact inside living cells

Levodopa in the active site of mitochondrial Phenylalanyl-tRNA synthetase. The lattice is the observed electron density corresponding to the L-Dopa

An accidental substitution in a new protein strand can spell disaster

Leptin receptor positive neuron in the mouse hypothalamus
Mice lacking the protein stayed slim, even on a high-fat diet.
Three-dimensional structure of an enzyme, serum paraoxonase (PON1), which has been mutated in the lab of Prof. Dan Tawfik through directed evolution to endow the enzyme with new functions

From solving the structure of crystallized proteins to creating computer simulations of protein dynamics, Institute scientists...