Molecular and Cell Biology

Mutations shed light on cancer

Rare Disease is a Lens on Cancer

24.11.2015

Cancer, Personalized Medicine, Systems Biology, Molecular and Cell Biology, Disease, Drugs & Diagnostics

In children, lack of a protein causes a dangerous disease. Why do cancer cells suppress the same protein?

Locations of different opsins on the human sperm, viewed under a microscope, are revealed by labeling with a fluorescent antibody (bright yellow)

Sperm “See” It Hot

24.10.2015

Molecular and Cell Biology, Fertility

Proteins better known as visual sensors play a role in the heat-seeking movement of sperm

Ubiquitin, labeled with a fluorescent marker (yellow), has been successfully delivered into cells.

The Real Thing

27.07.2015

Molecular and Cell Biology, Structural Biology

What do proteins look like in their natural environment?

bone loss_galectin

A Hitchhiker’s Guide to the Galectins

13.07.2015

Biochemistry, Molecular and Cell Biology, Disease, Drugs & Diagnostics

A protein ties osteoporosis to high blood sugar and the spread of cancer to the bone

New lung cells are continuously created to replace the damaged ones: Lung tissue six weeks after stem cell transplantation (left) and 16 weeks after transplantation (right). Cells that originated in the transplanted stem cells are green, as opposed to the uncolored host lung cells. Photon-2 microscope image

Stem Cells Might Heal Damaged Lungs

13.07.2015

Stem Cells, Molecular and Cell Biology, Immunology, Disease, Drugs & Diagnostics

Transplanted cells made their way to the lungs in mice and began producing healthy tissue

Metastatic melanoma cells. Image: NIH

Melanoma Mutations Mapped

08.07.2015

Cancer, Personalized Medicine, Molecular and Cell Biology, Disease, Drugs & Diagnostics

Scientists can now begin to make sense of the way a deadly cancer develops

PYK2 (red) and the cell-surface receptor (green) that triggers the cellular transition to a pro-metastatic state are found in the same membrane compartment (yellow) from which the transition signal is transmitted

Up Against a Triple Negative

08.07.2015

Cancer, Personalized Medicine, Molecular and Cell Biology, Disease, Drugs & Diagnostics

A signal stuck in the “on” position may hasten metastasis in certain breast cancers

Cultured colorectal cancer cells. Top: Cells that have become resistant to certain forms of chemotherapy and continue to thrive. Bottom: The same cells, which have had the LIP gene inserted and are then treated with chemotherapy drugs

Opposite Effects

02.07.2015

Cancer, Molecular and Cell Biology

What makes cancer cells survive chemotherapy?

Normal human colonic crypts. SMOC-2 expression (red) in the colonic stem cells demonstrates that these cells are localized in the bottoms of the crypts. Bars represent 100 micrometers (left) and 50 micrometers (right)

Colon Cancer: Taking a Step Back to Move Forward

29.06.2015

Cancer, Stem Cells, Molecular and Cell Biology

Some tumor cells in the advanced stages of colorectal cancer adopt a less mature, more stem-like, state that assists metastasis

A melanoma cancer cell is labeled with invadopodia markers in fluorescence microscopy

Support for an Invasion

14.06.2015

Cancer, Molecular and Cell Biology

How does a cancer cell push its way out of the surrounding tissue?

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Top Stories

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Phage’s Deep Pockets

Red alert, red herrings: Malarial RNA molecules (red dots) observed inside the nuclei (blue) of monocytes (green) using fluorescence confocal microscopy

Malaria’s mRNA: Messages that Mess with the Immune System

Press Releases

How Yeast Find the Perfect Match

Gut Microbes Actively Support Immunity in People Living with HIV

Prof. Igal Talmi, 1925–2026