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Biological Regulation


The Prize acknowledges Yarden's life-saving cancer research

Left: normal nerve cells; right cells genetically engineered to neutralize MTCH2. Fluorescent proteins reveal the calcium uptake in the mitochondria of these cells. The genetically engineered cells reveal dramatically less calcium uptake – evidence of the crucial role this gene plays in mitochondria function

Understanding how a gene studied in one lab affects the basic element researched in another may reveal what goes wrong in Alzheimer's 

Mutations shed light on cancer

In children, lack of a protein causes a dangerous disease. Why do cancer cells suppress the same protein?

Bone marrow EPCR+ hematopoietic (blood-forming) stem cell in an anticoagulant niche

How does the body keep replenishing the supply of blood cells all our lives? Two pathways must work together

A three-dimensional reconstruction of the mitochondrial volume: The volume is larger (yellow and red) in blood-forming stem cells lacking MTCH2 (right), and relatively smaller (blue and green) in regular blood-forming stem cells

The wake-up call for blood stem cells comes with a jolt of energy  

We share many of our genes with sea urchins, but none of the sequences for long non-coding RNAs that regulate those genes

Non-coding DNA sequences on an evolutionary “fast track” may hold clues to human disease

Immortalized cells, left, pretreated with a drug that blocks the ERK signal, and right, without the pretreatment. Top cells are untreated, while the bottom ones are stimulated

Weizmann Institute scientists identify a potential drug molecule that stops cancer cells, but not healthy ones, from getting their “mail”

A metastatic breast cancer cell under a fluorescent microscope.

The discovery of a new breast cancer gene holds hope for treatment

Water dynamics near an enzyme-collagen complex: The rates at which water molecules exchange hydrogen bonds with one another depend on the distance from the active site of the enzyme (gray) and on the type of collagen interacting with the enzyme; the different rates create a gradient of water motions, ranging from extremely fast (red) to very slow (blue and light-blue)

Water molecules in the body keep going after the main reaction is over