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Biological Regulation

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Israel Prize Awarded to Prof. Yosef Yarden
04.05.2017

The Prize acknowledges Yarden's life-saving cancer research

Left: normal nerve cells; right cells genetically engineered to neutralize MTCH2. Fluorescent proteins reveal the calcium uptake in the mitochondria of these cells. The genetically engineered cells reveal dramatically less calcium uptake – evidence of the crucial role this gene plays in mitochondria function
Balancing the Brain’s Calcium
23.04.2017
Biochemistry, Brain & Behavior, Systems Biology, Genetics

Understanding how a gene studied in one lab affects the basic element researched in another may reveal what goes wrong in Alzheimer's 

cancer-free prostate
Weizmann Institute Drug, TOOKAD® Soluble, Approved for Prostate Cancer Therapy in Mexico
04.01.2016
Life Sciences, Biochemistry, Cancer, Disease, Drugs & Diagnostics, Yeda Technology Transfer, Biotechnology, Diagnostic Techniques and Drugs

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Mutations shed light on cancer
Rare Disease is a Lens on Cancer
24.11.2015
Cancer, Personalized Medicine, Systems Biology, Molecular and Cell Biology, Disease, Drugs & Diagnostics

In children, lack of a protein causes a dangerous disease. Why do cancer cells suppress the same protein?

Bone marrow EPCR+ hematopoietic (blood-forming) stem cell in an anticoagulant niche
Blood-Forming Stem Cells' Balancing Act
03.11.2015
Cancer

How does the body keep replenishing the supply of blood cells all our lives? Two pathways must work together

A three-dimensional reconstruction of the mitochondrial volume: The volume is larger (yellow and red) in blood-forming stem cells lacking MTCH2 (right), and relatively smaller (blue and green) in regular blood-forming stem cells
Awakenings
09.09.2015
Stem Cells

The wake-up call for blood stem cells comes with a jolt of energy  

We share many of our genes with sea urchins, but none of the sequences for long non-coding RNAs that regulate those genes
Looking for Links
25.05.2015
Systems Biology, Molecular and Cell Biology, Evolution and Development, Genetics, Bioinformatics and Computational Biology

Non-coding DNA sequences on an evolutionary “fast track” may hold clues to human disease

Immortalized cells, left, pretreated with a drug that blocks the ERK signal, and right, without the pretreatment. Top cells are untreated, while the bottom ones are stimulated
To Stop Cancer: Block its Messages
30.03.2015
Cancer, Disease, Drugs & Diagnostics

Weizmann Institute scientists identify a potential drug molecule that stops cancer cells, but not healthy ones, from getting their “mail”

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A metastatic breast cancer cell under a fluorescent microscope.
Victory in Numbers
23.02.2015
Cancer, Genetics

The discovery of a new breast cancer gene holds hope for treatment

Water dynamics near an enzyme-collagen complex: The rates at which water molecules exchange hydrogen bonds with one another depend on the distance from the active site of the enzyme (gray) and on the type of collagen interacting with the enzyme; the different rates create a gradient of water motions, ranging from extremely fast (red) to very slow (blue and light-blue)
It Ain’t Over Till It’s Over
04.02.2015
Biochemistry

Water molecules in the body keep going after the main reaction is over

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The ions in the center of the cluster are cooled to the lowest temperatures, and can then be further accelerated in the ion beam trap

Colder and Colder

Humans and fish share about 70% of their protein-coding genes, but only about 0.5% of their regulatory long noncoding RNAs (lncRNAs)

Genomic Recycling: Ancestral Genes Take On New Roles

Cancerous tumor tissue under a microscope:

Altitude Training for Cancer-Fighting Cells

Bacteria in cancer cells

How Bacteria Hinder Chemotherapy

Press Releases

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The ions in the center of the cluster are cooled to the lowest temperatures, and can then be further accelerated in the ion beam trap
18.09.2017
Colder and Colder
Humans and fish share about 70% of their protein-coding genes, but only about 0.5% of their regulatory long noncoding RNAs (lncRNAs)
18.09.2017
Genomic Recycling: Ancestral Genes Take On New Roles
Cancerous tumor tissue under a microscope:
18.09.2017
Altitude Training for Cancer-Fighting Cells

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The Limits of Computing

Computers can solve complex problems but they are far from omnipotent. Prof. Ran Raz of the Weizmann Institute's Computer Science and Applied Mathematics Department is trying to portray the limits...

Israeli Researchers to Participate in European Commission Flagship

The European Commission has officially announced the selection of the Human Brain Project (HBP) as one of its two Future Emerging Technologies (FET) Flagship projects.

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Added particles in the atmosphere could be affecting rainfall patterns