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Molecular Genetics

Muscle fibers of a fruit fly larva viewed under a confocal microscope: A normal fiber has normally-shaped, properly distributed nuclei (A), whereas the nuclei of fibers with mutated MSP-300 or its interacting proteins Klar and Klaroid are distorted and distributed abnormally (B, C and D)

Why do muscles lose their strength without exercise?

Mouse islet of Langerhans; insulin-containing vesicles within beta cells are shown in white

Cells in the pancreas take on unusual shapes in order to carry out their vital work


Stem cell colony with cells in the process of differentiation; from the lab of Dr. Jacob Hanna

Before anything else, a stem cell must first put the brakes on its “stem-cell” program

Use It or Lose It

Why do muscles lose their strength without exercise?

Clusters of human embryonic stem cells that were differentiated to an early germ cell (PGC) state (colored cells). Each color reveals the expression of a different gene. (l-r) NANOS3, NANOG, OCT4 and, on the right, all three combined in a single image

A cell programming technique developed at the Weizmann Institute turns them into the earliest...

Algorithm-generated comparisons among the genomes of cells from 450 tissue samples: The analysis revealed a striking similarity (red colors, upper right rectangle) in tRNA signatures among cancerous cells and healthy dividing cells, as well as a degree of similarity among the non-dividing cells (red colors, lower left rectangle), whereas no such similarity (blue) was found when dividing cells were compared with non-dividing ones

Synonyms in the gene code spell differences in cell division

Fluorescent image of Baker's yeast cells showing that the yeast Presenilin-like protein, Ypf1 (green), is found in the same cellular area as Presenilin, around the nucleus

Weizmann Institute researchers reveal an unusual cellular mechanism that may be faulty in Alzheimer’s disease

Natural healing process of fractured bones. (A) Healing begins with a collection of blood and inflammation at the fracture site. (B) Soft callus (purple) is formed, which develops into the bidirectional growth plate at the concave side of the fracture site. (C) The growth plate drives bone growth in opposite directions. The result is a jack-like mechanical effect that moves the fragments toward straightening (red arrows). (D) New bone tissue is formed (orange). (E) The shape of the bone is fine-tuned by rem

Movement might actually help heal fractures in young bones

(l-r) Dr. Omer Markovitch and Eran Hadas

A scientist and an artist create art that imitates the very beginnings of life

Mapping cell death: The protein-protein interactions discovered and mapped out in Prof. Adi Kimchi’s lab (red lines are newly-revealed interactions) divulge the wealth of interconnections between two major cell death pathways

A unique method of mapping protein interactions reveals how two cellular pathways are interconnected