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Molecular Genetics

New Stem Cells Go Back Further
31.10.2013

Scientists isolate new human pluripotent stem cells capable of generating “humanized” mouse models containing human-derived tissues
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Pre-leukemic stem cells (top) with both mutated and healthy copies of the RUNX1 gene already display some of the characteristics of acute myeloid leukemia (AML). When the non-mutated copy of the gene is inactivated, disruptions in the spindle-assembly-checkpoint phase of cell division trigger cell death
29.09.2013

Weizmann Institute researchers discover that a “standoff” between a mutated gene and its normal counterpart keeps certain cancer cells alive...

Left column: Previous method for creating induced pluripotent stem cells (iPSCs); right column: iPSCs produced with the new method developed by Dr. Hanna. Top: Skin cells (red); center: iPSCs from skin cells (green); bottom: superimposed top and center images. Skin cells that have been reprogrammed into iPSCs appear light yellow. Only a small percentage of the cells on the left have been reprogrammed, in contrast with the high success rate seen with the new method on the right
17.09.2013

Weizmann Institute scientists show that removing one protein from adult cells enables them to efficiently turn back the clock to a stem-cell-like...

Bacterial Booby Traps Revealed
02.07.2013

Toxin-antitoxin gene pairs make a quick suicide mechanism for bacteria facing viral invasion

The tips of two adult fruit fly testes, viewed under a confocal microscope, are filled with dividing germ cells (green). About one quarter of these germ cells die by an alternative death pathway called germ cell death (pink and red)
05.06.2013
A newly discovered cell-death pathway could help fight cancer
Human cells light up with green fluorescent markers after being penetrated by a genetically engineered virus coated with the VSV envelope protein
05.06.2013

How does a helpful virus often used for gene therapy break into cells?

Dr. Frida Belinky
07.05.2013

A greatly expanded database will give scientists around the world a powerful new tool for life sciences research

Endoplasmic reticulum. Image: Nicolle Rager, National Science Foundation
08.04.2013

What happens when proteins don’t “go by the book?”

Yeast cell atlas: image by Michal Breker
08.04.2013

A new map of protein routes in the cell holds some surprises for researchers

Chromosome pairs: Does doubling them help or hurt? Image: Wikimedia commons
20.03.2013

Does a non-standard number of chromosomes help or hurt the cell?

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