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The molecular structure of Spanish flu protein (hemagglutin) bound to a computationally designed protein (green). The designed protein binds the viral protein tightly and with high specificity, blocking the protein's function and neutralizing viral infectivity

Matchmaker

23.05.2012
Biochemistry, Viruses & Microorganisms, Disease, Drugs & Diagnostics, Structural Biology
 A new method of redesigning protein molecules may yield novel drugs.
The two faces of BID. When duty calls, it leaves the cell nucleus to initiate cell suicide. Illustration: Elite Avni

Meeting Places

23.04.2012
Stem Cells, Molecular and Cell Biology, Disease, Drugs & Diagnostics
How does one protein direct two different life-or-death activities in the cell?
Profs. Bernardo Vidne and Talila Volk. From human hearts to fruit fly hearts

Heart and Mind

02.04.2012
Molecular and Cell Biology, Disease, Drugs & Diagnostics, Genetics, Science Teaching
After a career as a top cardiac surgeon, Prof. Bernardo Vidne decided to get a Ph.D. in science
Left: Natural control mechanism blocks the enzyme's zinc active site. Right: Novel antibody works as effectively as the natural control mechanism

Immune System Tricks

19.03.2012
Molecular and Cell Biology, Immunology, Disease, Drugs & Diagnostics, Structural Biology
A synthetic molecule causes a useful immune response in mice
Prof. Irun Cohen, DiaPep 227 developer

Phase III Clinical Trials of Diabetes Treatment

30.01.2012
Immunology, Disease, Drugs & Diagnostics, Yeda Technology Transfer, Biotechnology
Initial results show higher pancreas function after two years of treatment
Prof. Jeffrey Gerst and Rachel Kama

Unraveling Batten Disease

05.01.2012
Brain & Behavior, Molecular and Cell Biology, Disease, Drugs & Diagnostics, Genetics
When the CLN3 gene is mutated, molecular traffic patterns are disrupted in the neurons.
Left: Natural control mechanism blocks the enzyme's zinc active site. Right: Novel antibody works as effectively as the natural control mechanism

New Antibodies Treat Autoimmune Disease in Mice

26.12.2011
Immunology, Disease, Drugs & Diagnostics, Organic Chemistry
Institute scientist  “trick” the body into blocking an enzyme that abets disease processes
Electron microscope image of an effector cell inserting several appendages through endothelial cell membranes

Hide and Seek Signals

15.12.2011
Immunology, Disease, Drugs & Diagnostics
Keeping chemical signals inside the cells lining blood vessels ensures that only specially trained immune cells will find them
Andromeda Biotech: A Drug for Type 1 Diabetes Developed by Prof. Irun Cohen of the Weizmann Institute Meets Primary and Secondary Goals of Phase III Clinical Trials

Andromeda Biotech: A Drug for Type 1 Diabetes Developed by Prof. Irun Cohen of the Weizmann Institute Meets Primary and Secondary Goals of Phase III Clinical Trials

22.11.2011
Disease, Drugs & Diagnostics, Biotechnology
Pateints receiving the drug had significantly higher pancreas function than those in the control group.
Unraveling Batten Disease

Unraveling Batten Disease

02.11.2011
Brain & Behavior, Molecular and Cell Biology, Disease, Drugs & Diagnostics, Genetics
Experiments with a yeast gene reveal what goes wrong in a degenerative childhood disease. 

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